Electron Microscopy of the Kidney: In Renal Disease and by Anil K. Mandal M.D., F.A.C.P. (auth.)

By Anil K. Mandal M.D., F.A.C.P. (auth.)

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Additional resources for Electron Microscopy of the Kidney: In Renal Disease and Hypertension : A Clinicopathological Approach

Example text

On the other hand, a rapid rise in titers or a markedly elevated single titer (800-1000 Todd units) indicates active group A streptococcal infection. A high ASO titer is frequently present in acute poststreptococcal glomerulonephritis (60-80%) which follows a sore throat or proven pharyngitis. On the other hand, no more than 25% of acute glomerulonephritis preceded by streptococcal pyoderma demonstrate an elevated ASO titer. Antistreptohyaluronidase Antibody Antistreptohyaluronidase antibody (AH) is produced in response to streptococcal hyaluronidase.

CONTRAINDICATIONS Among the various contraindications enumerated in current textbooks and periodicals, the solitary kidney and an irreversible bleeding diathesis, in my experience, must still be considered as absolute contraindications. Many of the relative contraindications, such as tumor, cysts, or infection, should not always preclude the biopsy procedure if a definitive indication exists which warrants the additional risk. Renal biopsy is generally safe after a prolonged peritoneal dialysis or after two to three hemodialyses in cases of acute or chronic uremia, a condition that should no longer be regarded as a contraindication.

29: 189, 1976. Pollak, V. , Pirani, C. , Muehrcke, R. , and Kark, R. : Natural history of lipoid nephrosis and of membranous glomerulonephritis. Ann. Intern. Med. 69:1171, 1968. 27 RENAL BIOPSY Clinical Assessment of the Etiology and the Pathological Activity of Glomerulonephritis 3 The etiology and pathological activity of glomerulonephritis (ON) can be assessed by three different methods: (1) history and physical examination, (2) laboratory tests and their applications to determine the etiology of glomerulonephritis, and (3) laboratory tests to indicate the activity of the pathological process.

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