Design of Controlled Release Drug Delivery Systems by Xiaoling Li

By Xiaoling Li

The aim of each drug supply process is to convey the perfect quantity of a drug at a pre-programmed price to the specified position so that it will in achieving the drug point invaluable for the remedy. a vital consultant for biomedical engineers and pharmaceutical designers, this source combines physicochemical ideas with physiological tactics to facilitate the layout of structures that may bring drugs on the time and position it truly is so much wanted.

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Some limitations of using pharmacokinetics alone, along with examples of pharmacokinetics and pharmacodynamics used in the design of controlled release delivery systems, are provided in the following sections. 2 Limitations of using pharmacokinetics only to design controlled release delivery systems For a majority of drugs in controlled release delivery systems, pharmacokinetics alone have been sufficient to guide the choice of kinetically based design elements necessary to achieve therapeutically efficacious systems.

Biopharm. 16:475–492, 1988. 34. P. Veng-Pedersen. Noncompartmentally based pharmacokinetic modeling. Adv. Drug Deliv. Rev. 48:265–300, 2001. 35. K. Yamaoka, T. Nakagawa, and T. Uno. Statistical moments in pharmacokinetics. J. Pharm. Biopharm. 6:547–558, 1978. 36. N. Watari and L. Z. Benet. Determination of mean input time, mean residence time, and steady-state volume of distribution with multiple drug inputs. J. Pharm. Biopharm. 17:593-599, 1989. 37. H. Cheng, W. R. Gillespie, and W. J. Jusko. Review article: mean residence time concepts for non-linear pharmacokinetic systems.

Each is useful, but under specific conditions. These volume terms do not represent a specific physiological space; their utility is primarily the conversion of amount of drug into a concentration. Of these many volume terms, Vd,ss is probably the most relevant in the design of controlled release delivery systems. V1 and V2 (volume of distribution, compartments 1 and 2). V1 and V2 are the volume of distribution of compartments one and two, respectively (Eq. 16 150 0 50 100 150 Time Cp versus time for intravenous bolus input and two-compartment disposition.

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