Dendrimer-Based Nanomedicine by Istvan Majoros, James R. Baker Jr.

By Istvan Majoros, James R. Baker Jr.

In fresh a long time, dendrimers -- free-shaped man made macromolecules -- have garnered loads of clinical curiosity because of their designated molecular nanostructure. utilized in a number of medical functions, using dendrimers is now greatly considered as a more secure, extra unique, and more suitable strategy to perform medication.

This e-book compiles and information state of the art examine in technology and medication from the interdisciplinary group of the Michigan Nanotechnology Institute for medication and organic Sciences, who're presently revolutionizing drug supply suggestions in the course of the improvement of engineered nanodevices. Edited by means of Istvan J Majoros and James Baker, Jr., well-known nanotechnology researchers, this ebook will attract someone fascinated with nanotechnology, macromolecular technology, melanoma treatment, or drug supply study.

Contents: unique Drug supply quite often, New know-how in medication (B B Ward & J R Baker, Jr.); basic providers for Drug supply (T H Dunham et al.); Poly(amidoamine) Dendrimer Synthesis and Characterization (I J Majoros & D E Carter); Optical and Biophotonic functions of Dendrimer Conjugate (J Y Ye & T B Norris); Dendrimer Conjugates for melanoma remedy (I J Majoros et al.); organic program of PAMAM Dendrimer Nanodevices in vitro and in vivo (T P Thomas & J F Kukowska-Latallo); Dendrimer-based distinct Apoptosis Sensors for clinical program (A Myc et al.); MRI utilizing distinct Dendrimer distinction brokers (S D Swanson & C R Williams); Nanoparticle Membrane Interactions: Mechanism for greater Permeability (S Hong et al.); desktop Simulations of Dendrimers (S ok Kandasamy et al.); Dendrimer-Entrapped and Dendrimer-Stabilized steel Nanoparticles for Biomedical purposes (X-Y Shi & S H Wang).

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Mulé, and J. R. , Design and function of a dendrimer-based therapeutic nanodevice targeted to tumor cells through the folat receptor, Pharmaceutical Research, 19, 1310–1316, 2002. 8. J. Kukowska-Latallo, K. A. Candido, Z. Cao, S. S. Nigavekar, I. J. Majoros, T. P. Thomas, L. P. Balogh, M. K. Khan, and J. R. , Nanoparticle targeting of anticancer drug improves therapeutic response in animal model of human epithelial cancer, Cancer Research, 65, 5317–5324, 2005. 9. J. R. Grandis and D. J. Tweardy, Elevated level of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer, Cancer Research, 53, 3579–3584, 1993.

Foulds, Tumor progression, Cancer Research, 17, 355–356, 1957. 4. P. C. Nowell, The clonal evolution of tumor cell populations, Science, 194, 23–28, 1976. 5. B. Vogelstein and K. W. , 9, 138–141, 1993. 6. D. Hanahan and R. A. Weinberg, The hallmarks of cancer, Cell, 100, 57–70, 2000. 7. A. Quintana, E. Raczka, L. Piehler, I. Lee, A. Myc, I. Majoros, A. Patri, T. Thomas, J. Mulé, and J. R. , Design and function of a dendrimer-based therapeutic nanodevice targeted to tumor cells through the folat receptor, Pharmaceutical Research, 19, 1310–1316, 2002.

8 References Introduction Drug delivery by way of nanoparticles is a rapidly progressing area of research which unites researchers from the fields of chemistry, chemical engineering, biology, and medicine. Traditional drug therapies are often hindered by the natural processes of biochemical regulation within the body. qxd 3/31/2008 10:43 AM Page 36 FA István J. Majoros & Daniel E. Carter interferences as well as to enhance the productivity of therapeutic drug treatments. 1 Compared to traditional therapies, controlled drug delivery is usually a more effective, patient-friendly means of treatment.

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