
By Werner Krause (Editor)
BLECK: magazine OF the yankee CHEMICAL SOCIETY "...offers a pleasant review for starting graduate scholars and newbies to the field."
Read Online or Download Contrast Agents I: Magnetic Resonance Imaging (Topics in Current Chemistry, 221) PDF
Similar chemistry books
The Chemistry of Essential Oils and Artificial Perfumes - Volume 2 (Fourth Edition)
Quantity 2 (of the 2 quantity set): part titles are . .. (1) the fundamental Oil and Its scent . .. (2) elements of crucial Oils, artificial Perfumes and remoted Aromatics . .. (3) The research of crucial Oils.
Group 13 Chemistry I: Fundamental New Developments
During the last decade our view of chemistry has advanced considerably. while person researchers formerly concerned about particular components of chemistry, reminiscent of inorganic, natural, and so on. we now take a extra holistic method. potent and effective study tasks now comprise no matter what features of the chemistry subdisciplines which are had to whole the meant paintings.
- Macrocyclic polyether syntreses
- Optimization in Computational Chemistry and Molecular Biology: Local and Global Approaches
- Analysis of Drug Impurities (Sheffield Analytical Chemistry Series)
- Performance of a Practical Blind Watermarking Scheme
- Inorganic Chemistry of the Main-group Elements: v. 5 (Specialist Periodical Reports)
Extra resources for Contrast Agents I: Magnetic Resonance Imaging (Topics in Current Chemistry, 221)
Sample text
Frullano et al. The success of [Gd(DOTA)]– as a CA has initiated an intensive search for derivatives with improved properties, such as complexes of DO3A derivatives. The nonionic reagents Gd(HP-DO3A) and Gd(DO3A-butrol), in which one of the acetate groups of DOTA is replaced by a hydroxyalkyl group, have recently been introduced. The crystal structures of the parent Gd(DO3A) [67] and of the Gd(DO3MA) [83] derivatives show the 9-coordinate Gd3+ to be bound by the ligands in a heptadentate fashion.
The ligand tetracarboxyethyl DOTA derivative (TCE-DOTA) was synthesized as a mixture of the six stereoisomers defined by the absolute configuration of the four chiral carbons, RRRR/SSSS pair, RSSS/SRRR pair, RSRS and RRSS, which were separated, crystallized and their crystal structures determined [78, 79]. 5°) and opposite helicities [78, 79]. Thus, for an R configuration at carbon, the complex adopted a L (left-handed) arm helicity and a (dddd) chelate ring configuration. The (SSSS) enantiomer gave a D (right-handed) helicity and a (llll) chelate ring configuration.
This unusual behavior is ascribed to stacking properties of the carbostyril unit and to the presence of the a-oxygen atom in a position advantageous for coordination. The 13C NMR spectra of the La3+ and Lu3+ complexes of BOPTA display about 20 resonances in the aliphatic region at 60°C [28], which broaden upon lowering of the temperature. This suggests that a dynamic process is slowing down. It can be concluded that this compound occurs as at least two pairs of interconverting isomers [28]. In principle, the chirality in the benzyloxymethyl chain can give rise to doubling of the number of isomers, however, they are probably not observable in the NMR spectra of the diamagnetic La3+ and Lu3+ complexes due to small chemical shift differences between them.