Combinatorial Chemistry and Technology. Principles, Methods, by Stanislav Miertus, Giorgio Fassina

By Stanislav Miertus, Giorgio Fassina

"Provides complete assurance of the present combinatorial methodologies and applied sciences hired for the layout, synthesis, and screening of molecular ""libraries."" good points exams of computer-assisted techniques to guiding library synthesis. Designed to meet the call for to create, produce in excessive yield and purity, and quickly reveal large numbers of molecules."

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In 1966, Vayzankin and coworkers367,368 decomposed Et3 GeSH at 130 ° C to H2 S and Et3 GeSGeEt3 . The latter product also produced in the reaction of Et3 GeSH with Et2 Hg369 . Finally, hexaorganyldigermthianes R3 GeSGeR3 were obtained by the reaction of R3 GeSLi with R3 GeX (R D Me, Ph; X D Cl, Br)247,425 . In 1962, Henry and Davidson435 synthesized octaphenyltrigermdithian Ph3 GeSGePh2 SGePh3 , one of the first perorganyloligogermdithianes. They also obtained hexaphenyldigermperthiane Ph3 GeSSGePh3 having a Ge S S Ge group by the oxidation of Ph3 GeSH428,435 with iodine.

The alcoholysis of R3 MSR0 (M D Ge) was much more difficult than that for M D Si346,440 . Compounds R3 GeSR0 are easily oxidized by hydrogen peroxide up to R3 GeOGeR3 440 ; LiAlH4 reduces them to R3 GeH346 and aniline does not react with them. The Ge S bond of Ph3 GeSMe was so reactive that it was cleaved with methyl iodide to Ph3 GeI and Me3 SC I 440 . Similarly, dimethyl sulfate transforms Me3 GeSMe to Me3 GeOSO2 OMe440 and Me3 SC [MeSO4 ] . When organolithium or organomagnium compounds R0 M (R0 D alkyl; M D Li435 , MgX346 ) reacted with R3 GeSMe (R D Et, Ph), the SMe group was replaced by alkyl groups giving R3 GeR0 derivatives.

HCl and HBr reacted with RGeH3 and R2 GeH2 only in the presence of AlCl3 or AlBr3 276,358,359 . In 1953, Anderson337 found that the reaction of concentrated H2 SO4 with trialkylgermanes gave hydrogen and bis(trialkylgermyl) sulfates (R3 GeO)2 SO2 . According to Satge276 , the reaction of Et3 GeH and benzenesulfonic acid leads similarly to Et3 GeOSO2 Ph. (Et3 GeO)3 B was obtained by the reaction of Et3 GeH and H3 BO3 in the presence of copper powder360 . An analogous reaction of Et3 SiH and H3 BO3 in the presence of colloidal nickel was reported four years earlier361 .

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