By Stanislav Miertus, Giorgio Fassina
"Provides complete assurance of the present combinatorial methodologies and applied sciences hired for the layout, synthesis, and screening of molecular ""libraries."" good points exams of computer-assisted techniques to guiding library synthesis. Designed to meet the call for to create, produce in excessive yield and purity, and quickly reveal large numbers of molecules."
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Additional resources for Combinatorial Chemistry and Technology. Principles, Methods, and Applications
In 1966, Vayzankin and coworkers367,368 decomposed Et3 GeSH at 130 ° C to H2 S and Et3 GeSGeEt3 . The latter product also produced in the reaction of Et3 GeSH with Et2 Hg369 . Finally, hexaorganyldigermthianes R3 GeSGeR3 were obtained by the reaction of R3 GeSLi with R3 GeX (R D Me, Ph; X D Cl, Br)247,425 . In 1962, Henry and Davidson435 synthesized octaphenyltrigermdithian Ph3 GeSGePh2 SGePh3 , one of the ﬁrst perorganyloligogermdithianes. They also obtained hexaphenyldigermperthiane Ph3 GeSSGePh3 having a Ge S S Ge group by the oxidation of Ph3 GeSH428,435 with iodine.
The alcoholysis of R3 MSR0 (M D Ge) was much more difﬁcult than that for M D Si346,440 . Compounds R3 GeSR0 are easily oxidized by hydrogen peroxide up to R3 GeOGeR3 440 ; LiAlH4 reduces them to R3 GeH346 and aniline does not react with them. The Ge S bond of Ph3 GeSMe was so reactive that it was cleaved with methyl iodide to Ph3 GeI and Me3 SC I 440 . Similarly, dimethyl sulfate transforms Me3 GeSMe to Me3 GeOSO2 OMe440 and Me3 SC [MeSO4 ] . When organolithium or organomagnium compounds R0 M (R0 D alkyl; M D Li435 , MgX346 ) reacted with R3 GeSMe (R D Et, Ph), the SMe group was replaced by alkyl groups giving R3 GeR0 derivatives.
HCl and HBr reacted with RGeH3 and R2 GeH2 only in the presence of AlCl3 or AlBr3 276,358,359 . In 1953, Anderson337 found that the reaction of concentrated H2 SO4 with trialkylgermanes gave hydrogen and bis(trialkylgermyl) sulfates (R3 GeO)2 SO2 . According to Satge276 , the reaction of Et3 GeH and benzenesulfonic acid leads similarly to Et3 GeOSO2 Ph. (Et3 GeO)3 B was obtained by the reaction of Et3 GeH and H3 BO3 in the presence of copper powder360 . An analogous reaction of Et3 SiH and H3 BO3 in the presence of colloidal nickel was reported four years earlier361 .