Cell Signalling in Prokaryotes and Lower Metazoa by Ann Kays, Katherine A. Borkovich (auth.), Ian Fairweather

ADP. ComA-P activates the transcription of genes in the competence pathway.

1998) Signaling from G-protein-coupled receptors to mitogen-activated protein (MAP)-kinase cascade. Biochemical Pharmacology 56,269-277. , and Snyder, M. (1998) Cell polarity and morphogenesis in budding yeast. Annual Review of Microbiology 52, 687-744. R. (1997) MAP kinases with distinct inhibitory functions impart signaling specificity during yeast differentiation. Cell91, 673-684. , and Yamamoto, M. (1990) Adenylyl cyclase is dispensable for vegetative cell growth in the fission yeast Schizosaccharomyces pombe.

However, beyond the normal competition for resources inherent in any given environment, prokaryotic cells were 27 I. ), Cell Signalling in Prokaryotes and Lower Metazoa, 27-71. © 2004 Kluwer Academic Publishers. 28 CLAY FUQUA AND DAVID WHITE generally not considered to utilize any deliberate means of communication between cells. These longstanding views have been shattered by the recent evidence for a variety of intercellular signalling systems in prokaryotes. In fact, the idea of intercellular signalling among prokaryotes is not new.

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