By Wolf Herman Fridman M.D., Ph.D., Catherine Sautès Ph.D. (auth.)
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Extra resources for Cell-Mediated Effects of Immunoglobulins
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FcyRIIb3 is a soluble receptor lacking the TM region of FcyRIIb2. One gene encodes the IgG-binding a. chain of FcyRIII, which has 95% amino acid sequence homology with FcyRII in its ectodomains. It differs from FcyRII by its transmembrane and intracellular regions and because its expression requires association with an homodimer of y chains. In humans, three genes encode FcyRI isoforms, but only one transmembrane glycoprotein, homologous to the murine FcyRI, has been identified. Three genes encode FcyRII, where additional protein diversity is provided by alternative splicing of the first intracellular exon generating two transmembrane isoforms of FcyRIIB, FcyRIIbl and FcyRIIb2.