Cancer Drug Resistance: Overviews and Methods by Jose Rueff, António Sebastião Rodrigues

By Jose Rueff, António Sebastião Rodrigues

This quantity discusses the newest developments and applied sciences utilized in melanoma drug resistance learn. Cancer Drug Resistance: Overviews and strategies contains chapters that conceal subject matters equivalent to: learning the mechanics of resistance to DNA destructive healing medicines; experiences to delineate the function of efflux transporters; expression of drug transporters; resistance to distinctive treatments in breast melanoma; the position of microRNAs in present pancreatic melanoma therapy; and melanoma exosomes as mediators of drug resistance or medical and molecular equipment in drug improvement and using bioinformatics within the administration of melanoma drug resistance facts. Written within the hugely profitable Methods in Molecular Biology series layout, chapters comprise overviews of the most concerns in melanoma drug resistance and the respective mechanisms, in addition to introductions to their respective themes, lists of the mandatory fabrics and reagents, step by step, quite simply reproducible laboratory protocols, and tips about troubleshooting and heading off recognized pitfalls.

Authoritative and useful, Cancer Drug Resistance: Overviews and Methods, is a useful source to researchers, oncobiologists and scientific oncologists or an individual else who's drawn to the learn of melanoma and its drug resistances.

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The second switch, called the epithelial to mesenchymal transition (EMT), reflects a change towards more mesenchymal behavior and includes increased migratory and invasive potential. Within each category there may be differences in intrinsic cellular drug resistance [71, 72]. An important feature of these phenotypic switches is that they may be associated with multiple changes in resistance properties [71, 73]. General Protocols for Studying Resistance to Multiple Anticancer Drugs The field of drug resistance is very broad and it would be impossible in a limited space to recommend protocols for aspects of resistance.

Clin Breast Cancer 15:80–85 Dietlein F, Reinhardt HC (2014) Molecular pathways: exploiting tumor-specific molecular defects in DNA repair pathways for precision cancer therapy. Clin Cancer Res 20: 5882–5887 Kinzler KW, Vogelstein B (1997) Cancersusceptibility genes. Gatekeepers and caretakers. Nature 386(761):763 Dexheimer TS (2013) DNA repair pathways and mechanisms. In: Mathews LA, Cabarcas SM, Hurt EM (eds) DNA repair of cancer stem cells. Springer, Dordrecht, Netherlands, pp 19–32. 1007/978-94-007-4590-2_2 Lehner B (2011) Molecular mechanisms of epistasis within and between genes.

A third class of resistance involves activation of an alternate signaling pathway for cell proliferation and survival. Most examples are found in the use of targeted therapies; one example is provided in the MAP kinase pathway. Some tumors express a mutant form of the BRAF enzyme, one of the components of the MAP kinase pathway, and since cells become dependent on signaling by this overactive enzyme, their proliferation and survival are Mechanisms of Cancer Drug Resistance 27 compromised by inhibitors of the mutant enzyme [39].

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