
By Paul F. Torrence
Read or Download Biological Response Modifiers. New Approaches to Disease Intervention PDF
Similar nonfiction_10 books
Within the previous few years, substantial awareness has been paid to the presence of insulin-like progress elements (IGFs) and their binding proteins (IGF-BPs) within the mind and peripheral neuronal tissue. IGFs are synthesized in the CNS, are certain to particular IGF-BPs and act on particular receptors. They characterize a brand new category of progress elements and messengers within the mind and the outer edge.
Antibiotics and Chemotherapy: Current Topics
The aim of this e-book is to supply stories of assorted antibiotic issues to be able to be of curiosity to practicing clinicians and to microbiologists. it really is was hoping that adequate references were supplied to permit the fanatic to immerse himself within the resource literature. No test has been made to hide the entire box, that's good catered for within the various works at the topic.
- Turn Left at Orion: A Hundred Night Sky Objects to See in a Small Telescope - and How to Find Them
- Supercritical Fluid Extraction and its Use in Chromatographic Sample Preparation
- Climatic Change at High Elevation Sites
- The Transfer of Calcium and Strontium Across Biological Membranes
- Hemophilia Care in the New Millennium
- Insect Neurochemistry and Neurophysiology · 1986
Extra info for Biological Response Modifiers. New Approaches to Disease Intervention
Sample text
It is k n o w n that i m m a t u r e Β cells can be m a d e tolerant more easily t h a n mature Β cells. One possible mechanism by which tolerance to self-antigens may arise is t h r o u g h the limited capacity of Βμ cells (Section II,A,3) to resynthesize antigen receptors. Exposure of immature Βμ cells to antigen leads to capping and subsequent shedding of antigen-specific receptors. After 1 to 3 days, Β μ cells no longer have receptors or respond to antigen. Thus, the presence of self-antigens during maturation of the immune system may lead to paralysis of self-directed Β cells.
In contrast to lymphokines (Section V,D), which have no antigenic specificity, these regulatory factors have the same specificity for antigen as their T-cell parents. Some, but not all, carry idiotypic determinants and other determinants carried by the variable region of the antibody heavy-chain molecule. However, whether these factors are truly secreted by cells in vivo and are physiologically significant remains to be established. D. Antigen-Nonspecific Factors Many different cell types have the capacity to synthesize and secrete specific cell products in response to specific stimulation.
Monocytes can " t a k e residence" in tissues, where they become mature macrophages, but monocytes may also be " r e c r u i t e d " to tissues and differentiate into mature macrophages during the immune response (Fig. 6). Macrophages have receptors for complement and for the Fc portion of immunoglobulins, elevated levels of lysosomal enzymes, and, they are more active in phagocytosis t h a n monocytes. Monocytes may also fuse and become multinucleated giant cells. W h e n associated with different tissues, macrophages are given different names.