By C. A. Mims (auth.), D. A. J. Tyrrell (eds.)
This booklet files the papers and discussions at a piece store which came about in London at the fifth and sixth of April 1979, as a part of the programme of the fee of the ecu groups on scientific and Public healthiness study. but the perspectives expressed are these of the members involved and never of the EEC or any of its organs. the item used to be to debate convinced organic points of common and experimental sluggish virus infections. as the volume of information and the focal point of curiosity assorted in admire of every an infection the strategy and emphasis diverse additionally. on the subject of scrapie, we mentioned the character of the agent and the mode of pathogenesis, in terms of SSPE, the hunt for strange positive factors of the virus, and up to date aspect ed paintings at the immunology of the affliction. As for Visna we reviewed the current figuring out of the virus and its pathogenicity and in addition box epidemiology and techniques for its keep watch over. there have been additionally basic papers, on interferon and oncornaviruses for instance. We thank all those that made the assembly attainable and enabled us to supply this booklet quick, in order that those that couldn't attend the assembly could however have the ability to learn loads of what went on at it. specifically we'd thank the Ciba origin who allowed us using their premises and Mrs. Jean Ashley who handled many of the arrangements.
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Additional resources for Aspects of Slow and Persistent Virus Infections: Proceedings of the European Workshop sponsored by the Commission of the European Communities on the advice of the Committee on Medical and Public Health Research, held in London(U.K.), April 5–6, 1979
FIGURE . , . ~ 5: Spongiosis in the cerebellar cortex in an RIll mouse with 22L scrapie agent. ,-as 215 days. Haematoxylin and eosin, x 220. 43 There are complex interactions behveen the three variables 01 agent strain, host genotyp e and route 01 inoculation, but a lesion prolile 10r any particular combination is constant over a ,vide dose range. other lactors are held constant, When all an agent can olten be identilied on the basis 01 its l esi on prolile calculated as an average Irom a group 01 only 10 mice 01 a delined genotype.
P. titre ; injectio~ 35 In contrast, much more prolong e d incubation periods follow the use of slow agent combinations (such as 22A in Sinc s ? mice). Here, by the simple exped i ent of reducing the dose of initial i nfection to around 100 there is a prolonged interval , in excess of a year, LD50'~ during which the infectivity is not detected, but after which it rises rapidly in spleen to give a plat e au just as in the quicker combinations ( Figure 2) . These are the types of circumstances in which the full sequence of events involving eNS replication and eventual neurological deterioration do not occur because of the limits imposed by l ife span (4).
In: Slow transmissible diseases of the nervous system, Hadlow, WJ, SB Prusiner (eds), New York, Academic Press, in press. 43. Gajdusek, DC: Unconventional viruses and the origin and disappearance of kuru. Science 197: 943-960, 1977. 44. Fraser, H: Scrapie: a transmissible degenerative CNS disease. In: Progress in neurological research, Behan, PO, F Clifford Rose (eds) , London, Pitman, in press. 45. Dickinson, AG, VMH Meikle, H Fraser: Identification of a gene which controls the incubation period of some strains of scrapie agent in mice.