Advances in Synthetic Organic Chemistry and Methods Reported by Thomas F. DeRosa

By Thomas F. DeRosa

Advances in artificial natural Chemistry and techniques said in US Patents presents artificial directions for getting ready present and commercially major natural compounds, derivatives, and intermediates as pronounced in issued US Patents. Industries surveyed comprise agrochemical, cosmetics and private care items. every one access comprises huge info reminiscent of particular laboratory instructions for getting ready all chemical intermediates and characterization information. moreover, product optimization reviews, commercial practise, and new artificial tools were incorporated for chosen entries, in addition to projected study instructions for destiny product improvement. In Advances in man made natural Chemistry and techniques suggested in US Patents the author's useful strategy permits readers to spot examine and marketplace tendencies, and remain updated on present advancements within the box. * presents man made instructions for getting ready present and commercially major natural compounds, derivatives, and intermediates as suggested in issued US Patents * Identifies product improvement developments to aid verify learn parts * Elucidates use of the USA Patent and Trademark workplace database

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5. 0122 mol) was dissolved in 10 ml ethyl alcohol and 11 ml 1 M NaOH added. The mixture was refluxed for 2 hours then evaporated to dryness. The crystals were washed with EtOAc and diethyl ether and isolated, mp = 257–259 C. Derivatives R1 Ethyl Methyl Ethyl Ethyl Amine R2 4-Fluorophenyl 3,5-Dichlorophenyl 4-Fluorophenyl 4-Fluorophenyl 3-Methylphenyl R3 Carboxylic acid Carboxylic Acid Ethoxycarbonyl Carboxylic acid Carboxylic acid MP C 155–156 207–209 130 207–209 161 16 ADVANCES IN SYNTHETIC ORGANIC CHEMISTRY Notes 1.

The hexanes were removed and the product isolated as a flocculent white crystal in 60% yield, mp = 54 6 C. 8. 0 L ethyl alcohol then heated to 70–75 C for 8 hours. 42 L 8% NaHCO3 was added and ethyl alcohol distilled off. 5 L water, dried, and concentrated to yield a mixture of isomeric hydroxyl azides in quantitative yield as a brown oil. 9. 92 L acetonitrile added dropwise over 2 hours. 35 L), and filtered to remove triphenylphosphine oxide. 8% yield. 10. 66 l water added. 05 L CH2 Cl2 added.

Terranova et al, US Patent 5,466,694 (November 14, 1995) M. Hocquaux et al, US Patent 5,772,990 (June 30, 1998) D. Dufetel et al, US Patent 5,760,043 (June 2, 1998) ADVANCES IN SYNTHETIC ORGANIC CHEMISTRY 14 1,2-Diarylmethylene Derivatives, Their Methods of Preparation, and Their Uses in Therapeutics E. Nicolai et al, US Patent 5,972,950 (October 26, 1999) Assignee: Laboratories UPSA Utility: Anti-Inflammatory and Analgesic Agents Patent: Reaction i- CH2 Cl2 , aluminum chloride ii- CH2 Cl2 , 3-chloroperbenzoic acid iii- Ethyl succinate, potassium t-butoxide, t-butyl alcohol iv- THF, borane/dimethyl sulfide v- Sodium hydroxide, ethyl alcohol Experimental 1.

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