By V. I. Ivanov, N. A. Liapunova (auth.), Professor Dr. Günter Obe (eds.)
Utilized genetic study, genetic toxicology and mutation learn examine the mutagenicity and cancerogenicity of chemical compounds and different brokers. everlasting mutation in genes and chromosomes, will be prompted by means of aplethora of brokers, together with ionizing and nonionizing radiations, chemical compounds, and viruses. one of the points discused by means of Advances in Mutagenesis learn are (1) the certainty of the molecular mechanisms resulting in mutations, and (2) the prevention of a inconsiderate creation of mutagenic brokers into the surroundings. Contents: Nikolay W. Timofeeff-Ressovsky (1900-1981): An Essay on his existence and medical Achievements. - Arylnitrenium Ions and the Genotoxic efficiency of fragrant Amines and Nitro Compounds. - Analysisof Mutagenicity and Chemical constitution in quite a few sequence of similar Compounds. - Formation of 8-Hydroxyguanine by way of Oxidative DNA harm, its fix and its Mutagenic results. - Exploring Genetic and Non-Genetic Relationships: The Induction of Micronuclei. - Mechanisms of precipitated Mutagenesis through Ultraviolet mild in Escherichia coli. - Polytene Chromosomes in Mutagenesis. Three-Way Differential Stainingof Chromosomes for the id of SCEs in line with mobile Cycle: basics and purposes. - The Mammalian Centromere: Centromere Separation, Kinetochore Proteins and Aneuploidy. - Chorionic Villi research. - ExploringGenetic and Non-Genetic Relationships: The Induction of Micronuclei.
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1987a). The noncarcinogenic oxidants NaClO and NaClO z did not induce appreciable formation of oh 8 Gua in rat kidney DNA. Similarly, there are reports of oh 8 Gua formation in DNA of target organs of rats after administration of several other chemical carcinogens, such as ciprofibrate (liver) (Kasai et al. 1989), simfibrate (liver) (Takagi et al. 1989), 2-nitropropane (liver) (Fiala et al. 1989), Fe-nitrilotriacetate (kidney) (Umemura et al. 1990), 1, 6-dinitropyrene (mammary gland) (Djuric and Potter 1990), and choline-deficient diet (liver) (Hinrichsen et al.
Age-associated increases of oh 8 Gua in the DNA of rat organs (Fraga et al. 1990) and in mitochondrial DNA of human diaphragm (Hayakawa et al. 1991b) have also Formation of 8-Hydroxyguanine by Oxidative DNA Damage 43 been observed. oh 8 Gua is also produced in DNA of rat organs after administration of chemical carcinogens that form oxygen radicals. Therefore, analysis of oh 8 Gua in animals may be useful in predicting the carcinogenic potencies and target organs of oxygen radical forming chemicals.
Most of these mutations were GC-T A transversions as shown by sequence analyses of these revertant DNAs. Results from a similar method showed that thymine glycol induces AT -GC transition by base pairing with guanine by Wobble-type hydrogen bonding (Basu et al. 1989), but that 5-hydroxymethyluracil does not induce mutations (Levy and Teebor 1991). Moriya et al. (1991) prepared plasmid DNA with a six-nucleotide gap opposite ohBGua and transfected it into E. coli. After replication of the plasmid, the sequence of DNA corresponding to the gap was determined by the oligonucleotide hybridization method.